β-Eudesmol is an open and closed channel blocker, like phencyclidine, related to acetylcholine receptor at endplates of single skeletal muscle cells of adult mice
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چکیده
منابع مشابه
Expression of acetylcholine receptor isoforms at extraocular muscle endplates.
PURPOSE To determine the expression of fetal and adult acetylcholine receptor (AChR) isoforms among extraocular muscle (EOM) en plaque and en grappe endplates. METHODS Antibodies against peptide fragments of the gamma- and epsilon-subunits of the fetal and adult AChRs and alpha-bungarotoxin were used in immunofluorescence experiments to stain rat neonatal leg, adult diaphragm, and extraocular...
متن کاملLamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor.
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase...
متن کاملTopographical segregation of old and new acetylcholine receptors at developing ectopic endplates in adult rat muscle
We have used radioautographic methods to examine the topography of addition and removal of acetylcholine receptors (AChRs) within receptor clusters at developing ectopic synapses in adult rat soleus muscle. After AChRs within a cluster had been pulse-labeled with 125I-alpha-bungarotoxin (125I-alpha-BuTx), the area that they occupied within the cluster shrank with time. Thus the old receptors at...
متن کاملGlutamatergic reinnervation and assembly of glutamatergic synapses in adult rat skeletal muscle occurs at cholinergic endplates.
After denervation of adult rat abdominal muscles, the postsynaptic apparatus of neuromuscular junctions (NMJs) retains its original architecture and clustering of acetylcholine receptors (AChRs). When descending fibers of the spinal cord are surgically diverted to this muscle by a nerve grafting procedure, supraspinal glutamatergic neurons can innervate muscle fibers and restore motor function;...
متن کاملA postnatal change in the immunological properties of the acetylcholine receptor at rat muscle endplates.
We have used a myasthenic serum that in adult rat muscle is specific for acetylcholine receptors (AChRs) in the extra-junctional membrane to characterize the AChRs at developing endplates. Immunocytochemical experiments show that AChRs at endplates in the rat diaphragm bind the myasthenic antibodies during the first week after birth but lose their reactivity during the second and third postnata...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)55279-9